Near-infrared spectroscopy-based nondestructive at-line analysis of physicochemical properties of atorvastatin calcium hydrate after grinding
نویسندگان
چکیده
The purpose of this study was to monitor the physicochemical properties atorvastatin calcium sesquihydrate (ATC) ground products during grinding and explore polymorphous formation caused by intermolecular interactions. Changes in properties, such as surface adsorbed channel water content ( AW ), lattice BW crystallinity XRD% apparent solubility Cs were evaluated via X-ray diffractometry, thermogravimetry, near-infrared (NIR) spectroscopy, initial dissolution kinetic methods. Partial least-squares regression calibration models created using NIR predict properties. molecular behaviors these analyzed vectors. transformation into mechanical energy, where crystalline ATC transformed an amorphous solid. increased significantly with increasing time. Based on spectroscopy results, transition crystals induced cleavage Furthermore, over longer times, polymorphic transitions solids highly soluble intramolecular interactions between complex. • Polyamorphious prepared dry-grinding. Near-infrared detects both Physicochemical associate hydration manner. evaluate spectroscopy.
منابع مشابه
Nondestructive Firmness Estimation of Tomato Fruit Using Near-Infrared Spectroscopy
Today, nondestructive methods are widely used to determine the quality of agricultural products. Meanwhile, visible and near-infrared (Vis/NIR) spectroscopy is regarded as one of the most widely used methods in the field of quality assessment of agricultural products. In this study, a system was developed to measure the Vis/NIR spectra of tomato fruit samples in the half-transmittance mode of m...
متن کاملbrain near-infrared spectroscopy (nirs)
near-infrared spectroscopy (nirs) is a spectroscopic method that uses the near-infrared region of the electromagnetic spectrum. typical applications include medical and physiological diagnostics. nirs can be used for non-invasive assessment of brain function through the intact skull in human subjects by detecting changes in blood hemoglobin concentrations associated with neural activity, e.g., ...
متن کاملDetermining Blood Glucose Concentration using Near Infrared Spectroscopy: Early Findings
Introduction: Diabetes mellitus is one of the diseases that have grown dramatically in today's societies. People with diabetes should continuously measure their blood glucose level. Continuous blood glucose measurement by commonly used methods is painful and difficult. On the other hand, mobile phone can be a useful tool for accessing physicians and telemedicine services more easily. The aim of...
متن کاملDetermining Blood Glucose Concentration using Near Infrared Spectroscopy: Early Findings
Introduction: Diabetes mellitus is one of the diseases that have grown dramatically in today's societies. People with diabetes should continuously measure their blood glucose level. Continuous blood glucose measurement by commonly used methods is painful and difficult. On the other hand, mobile phone can be a useful tool for accessing physicians and telemedicine services more easily. The aim of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Drug Delivery Science and Technology
سال: 2022
ISSN: ['1773-2247', '2588-8943']
DOI: https://doi.org/10.1016/j.jddst.2022.103266